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Nancy E. Lee

Nancy E. Lee
Title
Associate Professor
Phone
617-521-2732
Office
Science Center S440
Email
Web
http://www.simmons.edu/~lee

Education

NIH Postdoctoral Fellow, 1993-1994
Massachusetts Institute of Technology, Cambridge, Massachusetts

Ph.D.
Brown University

B.A.
University of Pennsylvania


Research

  • new synthetic methodologies
  • synthesis of green polymers

Recent Publications

(boldface names are Simmons students)

"Study of Solvent-Free Asymmetric Reduction of 1-Acetonaphthone" Ugne Aleknaite, Virgnia Liu, Katelyn Thomas, Daisy Bourassa, Richard Gurney, and Nancy E. Lee† Journal of Undergraduate Chemistry Research, 2012, 11(3), 78

"Using Green Chemistry Principles as a Framework to Incorporate Research into Organic Laboratory Curriculum" Nancy E. Lee and Rich Gurney. Journal of Chemical Education, currently under review (2012)

"Evolution of the Women in Materials Program: a Collaboration between Simmons College and the Cornell Center for Materials Research", Leonard Soltzberg, Velda Goldberg, Michael D. Kaplan, Richard W. Gurney, Nancy E. Lee, George Malliaras, Helene Schember, in Materials Education, edited by M. Marinho Patterson, D. Dunham, E. Marshall, J. Nucci (Mater. Res. Soc. Symp. Proc. Volume 1233, Warrendale, PA, 2010), 1233-PP10-05.

"Stereoselective Reduction of Steroidal Side Chains Containing a,ß-Alkynone System", Ayako Honda, Annise Berger, Tamara Gooding, and N.E. Lee, Journal of Undergraduate Chemistry Research 2005, 6, 123.

"Predictive Modeling of Chemical Reactions", N.E. Lee, Ayako Honda, Michelle Sanford, Mojisola Sekoni, L.J. Soltzberg, Journal of Undergraduate Chemistry Research 2003, 2, 141.

"Synthesis and Biological Activities of two C(23) epimers of 1a,23,25(OH)3-24-Oxo-19-norVitamin D 3: Novel Analogs of 1a,23(S),25(OH)3-24-Oxo-Vitamin D3, a Natural Metabolite of1a, 25 (OH)2-Vitamin D3"  N. E. Lee, G. S. Reddy, D. S. Rao, A. J. Brown, M. J. Campbell, H. P. Koeffler, S. Peleg, and P. G. Williard,  Steroids 2000, 65, 252.

"Practical Approaches to Asymmetric Induction in Steroidal Side-Chains Utilizing Oxazoborolidine Reagents," M.N. Rao, M.A. McGuigan, X. Zhang, W.A. Kinney, M. Bulliard, B. Laboue, and N.E. Lee, J. Org. Chem. 1997 62, 4541.

"Synthesis, Stereochemistry, and Biological Activity of 1,23,25-Trihydroxy-24-oxovitamin D3, a Major Metabolite of 1,25-Dihydroxyvitamin D3," N.E. Lee, G.S. Reddy, A.J. Brown, and P.G. Williard, Biochemistry 1997 36, 9429.

Presentations 

"Synthesis and characterization of 1,3-bis(4-vinylbenzyl)thymine and its polymerization with vinylbenzyl triethylammonium chloride" Ngoc Chau Vy, Nancy Lee, Richard Gurney, 244th American Chemical Society Fall National Meeting, Philadelphia, PA, Augst 19-23, 2012, CHED 351.

"Using Green Chemistry Principles as the Framework to Incorporate Research into the Organic Laboratory and the Resultant Effects on the Entire Undergraduate Chemistry Curriculum."Rich Gurney, Nancy Lee, Changqing Chen and Cheryl Lavoie, 244th American Chemical Society Fall National Meeting, Philadelphia, PA, Augst 19-23, 2012, CHED 141.

"Characterization of copolymers of vinylbenzyl thymine (VBT) and vinylbenzyl chloride (VBC) using size exclusion chromatography." McLaughlin, Amanda L.; Gurney, Richard W.; Lee, Nancy; Chen, Changqing. 243rd ACS National Meeting & Exposition, San Diego, CA, United States, March 25-March 29, 2012, CHED-331.

"FT-IR study and chemometric analysis of photoinduced crosslinking in thymine copolymers." McDonough, Kris; Bortolato, Santiago A.; Thomas, Katelyn; Lee, Nancy; Gurney, Rich; Martino, Debora. 243rd ACS National Meeting & Exposition, San Diego, CA, United States, March 25-March 29,
2012, CHED-1120

"Integration of vinylbenzyl thymine research in undergraduate organic chemistry laboratories." Nowakowski, Veronica C; Vy, Ngoc Chau; Werner, Melissa; Huynh, Anna; Koelln, Rebecca; Yasi, Emily; Kirch, Vera; Chen, Changqing; Lee, Nancy; Gurney, Rich. 243rd ACS National Meeting &
Exposition, San Diego, CA, United States, March 25-March 29, 2012, CHED-1167.

"Characterization of copolymers of vinylbenzyl thymine (VBT) and vinylbenzyl chloride (VBC) using MALDI-TOF MS." Thistle, Katrina; Lee, Nancy; Gurney, Rich; Chen, Changqing. 243rd ACS National Meeting & Exposition, San Diego, CA, United States, March 25-March 29, 2012, CHED-1224.

"Undergraduate Laboratory Renaissance for Organic Chemistry" by Nancy Lee and R. Gurney. October 19, 2011 Council of Undergraduate Research (CUR) as part of ISSoTL symposium (International Society for the Scholarship of Teaching and Learning) Milwaukee, Wisconsin, USA for the 2011 ISSOTL Conference, Transforming the Academy Through the Theory and Practice of SOTL, October 20-23, 2011.

"Undergraduate laboratory renaissance for organic chemistry." Gurney, Richard W.; Lee, Nancy E.; Chen, Changqing. 242nd ACS National Meeting & Exposition, Denver, CO, August 28-September 1, 2011 CHED-121.

"Solid Reductions of Ketones Using Sodium Borohydride/Boric Acid with Chiral Reagents." Virginia Liu, Katelyn Thomas, Daisy Ellisor, Ugne Aleknaite, Bib Yang, Richard Gurney and Nancy Lee., 240th ACS National Meeting, Boston, Ma, August 22-25, 2010.

"Undergraduate Laboratory Renaissance for Organic Chemistry." Nancy Lee and Rich Gurney. 240th ACS National Meeting, Boston, Ma, August 22-25, 2010

"Undergraduate Laboratory Renaissance" Leonard J. Soltzberg, Nancy E. Lee, and Richard W. Gurney, Association of American Colleges and Universities Conference, "Engaging Science, Advancing Learning: General Education, Majors, and the New Global Century." Providence, RI November 6-8, 2008.

Grants

Presidential Fund for Faculty Excellence, " Thymine Based Bioinspired Polymers," $15,000 (2011)

W.M. Keck Foundation, "Undergraduate Laboratory Renaissance," $244,000, (2008)

Presidential Fund for Faculty Excellence, "Green Asymmetric Synthesis," $14,744 (2007)


Patents

"Stereoselective synthesis of 24-hydroxylated compounds useful for the preparation of aminosterols, vitamin D analogs and other compounds" W. A. Kinney, S. Jones, X. Zhang, M. N. Rao, M. Bulliard, H. Mechler, N. E. Lee U.S. Patent, WO 98/24800 1997

"Catalytic Asymmetric Reduction of Enamines" N.E. Lee, S. L. Buchwald U.S. Patent 5,489,682, Feb 6, 1996.

"Catalytic Asymmetric Reduction of Trisubstituted Olefins" R. O. Broene, N.E. Lee, S. L. Buchwald International Patent WO 95/02567 Jan., 1995.

"4-Azatricylco[4.3.1.1(3,8)]undecylarylpiperazines with Anxiolytic Activity"Kinney, W. A.; Lee, N. E. U.S. Patent 5,021,569, June 4, 1991.

"2-Pyridinecarbothioamides, Process for Preparation thereof and Pharma-ceutical Compositions Comprising the Same" Kinney, W. A.; Lee, N. E. U.S. Patent 4,958,023, September 18, 1990.

"2-Pyridinecarbothioamides and Pharmaceutical Compositions Comprising the Same" Kinney, W. A.; Lee, N. E. U.S. Patent 4,873,238, October 10, 1989.