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Mary Owen

Mary Owen
Science Center, S255

Assistant Biologist (Research Appointment), Department of Genetics and Teratology, Pediatric Service, Massachusetts General Hospital$0


M.S., Ph.D., Developmental Biology
Clark University

B.S., Biology
Regis College


  • Patterning of the vertebrate embryo and developmental events that lead to the abnormal limb
  • Development of novel in vivo imaging techniques for trafficking of neural stem cells


(maiden name Wesolowski)

Wesolowski MH, Lyerla TA. The developmental appearance of hexokinase and alcohol dehydrogenase in Xenopus laevis. J. Exp. Zool. 1980; 210:211-219.

Wesolowski MH, Lyerla TA. Alcohol dehydrogenase isozymes in the clawed frog, Xenopus laevis. Biochem. Genet. 1983; 21(9/10):1003-1017.

Sapirstein VS, Stocchi P, Wesolowski M, Gilbert JM. The characterization and biosynthesis of soluble and membrane-bound carbonic anhydrase in brain. J. Neurochem. 1983; 40(5):1251-1261.

Vishwanatha JK, Coughlin SA, Wesolowski-Owen M, Baril EF. A multiprotein form of DNA polymerase from Hela cells. Journal of Biological Chemistry 1986; 261(14):6619-6628.

Owen MH, Holmes LB. Stage and dose dependent effects of all-trans retinoic acid on expression of Dominant hemimelia in mice. Teratology 1998; 57(2):108.

Owen MH, Holmes LB. Restricted pattern of expression of tibia hypoplasia and reduced number of vertebrae produced by Dominant hemimelia. Teratology 1998; 57(2):107.

Morin BJ, Owen MH, Raumamurthy GV, Holmes LB. Pattern of skeletal malformations produced by Dominant hemimelia (Dh). Teratology 1999; 60(6):348-355. (Owen, Corresponding Author)

Owen MH, Coull BA, Holmes LB. Evidence for sex based differences in expression of Dominant hemimelia. Birth Defects Research: Clinical and Molecular Teratology 2006; 76 (5):398.

Owen MH, Coull BA, Holmes LB. Asymmetry of skeletal effects of Dominant hemimelia. Birth Defects Research: Clinical and Molecular Teratology 2006; 76 (6):474-482.

Cicchetti F, Gross RE, Bulte JWM, Owen M, Chen I, Saint-Pierre M, Wang X, Yu M, Brownell A-L. Dual modality in vivo monitoring of subventricular zone stem cell migration and metabolism. Contrast Media and Molecular Imaging 2007; 2(3): 130-8.

Owen MH, Ryan LM, Holmes LB.  Effects of retinoic acid on Dominant hemimelia expression in mice.  Birth Defects Research:  Clinical and Molecular Teratology 2009; 85:36-41.

Field Courses

Biol 345 Tropical Marine Biology. Offered in Spring 1996, 1998, 2004, 2006. Satisfies 300 level elective in Biology and is a Short-Term Course, pre-requisite Biol 218. Explores the interrelationships of marine organisms and their environment. Includes lecture and laboratory components at Simmons College and a ten-day field trip experience at the Gerace Research Station on the island of San Salvador, Bahamas. Provides the opportunity to explore the open ocean and coral reefs and contributes to a better understanding of the delicate biological balance on isolated islands. Communities studied included the fringing, patch and marginal reefs, mangrove ponds, bat caves, cay islands, sea grass beds and rocky intertidal. (see

Biol 105 Environmental and Public Health in Costa Rica. To be offered in Spring 2007, satisfies Mode 4 and is a Short-Term Course, no pre-requisites. Provides an ecological perspective on environmental health. Introduces cycles of life, impact of man's activities on the environment and the effect of those environmental factors on human health. Students develop projects that examine the impact of agricultural and industrial development on tropical ecosystems and on human health in Costa Rica.

Consulting Work

Proctor and Gamble First Grade Germ Program (1997-00)