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Faculty

Nancy E. Lee

Nancy E. Lee
Title
Associate Professor
Phone
 617-521-2732
Fax
 617-521-3086
Office
 Science Center S440
Email
Web
http://www.simmons.edu/~lee



Education

Ph.D., Brown University

B.A., University of Pennsylvania


Research

  • new synthetic methodologies
  • medicinal chemistry

Recent Publications

(boldface names are Simmons students)

"Stereoselective Reduction of Steroidal Side Chains Containing a,ß-Alkynone System", Ayako Honda, Annise Berger, Tamara Gooding, and N.E. Lee, Journal of Undergraduate Chemistry Research 2005, 6, 123.

"Predictive Modeling of Chemical Reactions", N.E. Lee, Ayako Honda, Michelle Sanford, Mojisola Sekoni, L.J. Soltzberg, Journal of Undergraduate Chemistry Research 2003, 2, 141.

"Synthesis and Biological Activities of two C(23) epimers of 1a,23,25(OH)3-24-Oxo-19-norVitamin D 3: Novel Analogs of 1a,23(S),25(OH)3-24-Oxo-Vitamin D3, a Natural Metabolite of1a, 25 (OH)2-Vitamin D3"  N. E. Lee, G. S. Reddy, D. S. Rao, A. J. Brown, M. J. Campbell, H. P. Koeffler, S. Peleg, and P. G. Williard,  Steroids 2000, 65, 252.

"Practical Approaches to Asymmetric Induction in Steroidal Side-Chains Utilizing Oxazoborolidine Reagents," M.N. Rao, M.A. McGuigan, X. Zhang, W.A. Kinney, M. Bulliard, B. Laboue, and N.E. Lee, J. Org. Chem. 1997 62, 4541.

"Synthesis, Stereochemistry, and Biological Activity of 1,23,25-Trihydroxy-24-oxovitamin D3, a Major Metabolite of 1,25-Dihydroxyvitamin D3," N.E. Lee, G.S. Reddy, A.J. Brown, and P.G. Williard, Biochemistry 1997 36, 9429.


Patents

"Catalytic Asymmetric Reduction of Enamines," N.E. Lee and S. L. Buchwald, U.S. Patent 5,489,682, Feb. 1996.

"Catalytic Asymmetric Reduction of Trisubstituted Olefins," R. O. Broene, N.E. Lee and S. L. Buchwald, International Patent WO 95/02567 Jan. 1995.

"4-Azatricylco[4.3.1.1(3,8)]undecylarylpiperazines with Anxiolytic Activity," W. A. Kinney and N. E. Lee, U.S. Patent 5,021,569, June 1991.